Chiral Tetraazamacrocycles Having Four Pendant-Arms

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• 作者：Seiji Kamioka ; Takashi Takahashi ; Susumu Kawauchi ; Hiroaki Adachi ; Yusuke Mori ; Kotaro Fujii ; Hidehiro Uekusa ; Takayuki Doi
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：June 4, 2009
• 年：2009
• 卷：11
• 期：11
• 页码：2289-2292
• 全文大小：172K
• 年卷期：v.11,no.11(June 4, 2009)
• ISSN：1523-7052

文摘

A chiral tetraazamacrocycle 9 having four pendant-arms was synthesized by repeating ring opening of an Ns-aziridine with secondary amines, followed by macrocyclization. The structure of 9 has been determined by single crystal X-ray diffraction analysis and NMR studies. Sugar-hybrid molecules 12a−12f were synthesized based on the scaffold 9. NMR study showed that 12a−12f keep the similar conformation as 9 in solution.