Direct Synthesis of Trisubstituted Isoxazoles through Gold-Catalyzed Domino Reaction of Alkynyl Oxime Ethers

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• 作者：Masafumi Ueda ; Aoi Sato ; Yuki Ikeda ; Tetsuya Miyoshi ; Takeaki Naito ; Okiko Miyata
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：June 4, 2010
• 年：2010
• 卷：12
• 期：11
• 页码：2594-2597
• 全文大小：178K
• 年卷期：v.12,no.11(June 4, 2010)
• ISSN：1523-7052

文摘

Alkynyl oxime ether underwent a gold-catalyzed domino reaction involving cyclization and subsequent Claisen-type rearrangement to afford trisubstituted isoxazoles in a direct, efficient, and regioselective manner. The products were successfully applied to the synthesis of unusual heterocycles as an illustration of the potential utility of the reaction.