Photocurable Biodegradable Liquid Copolymers: Synthesis of Acrylate-End-Capped Trimethylene Carbonate-Based Prepolymers, Photocuring, and Hydrolysis

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• 作者：Takehisa Matsuda ; Il Keun Kwon ; and Satoru Kidoaki
• 刊名：Biomacromolecules
• 出版年：2004
• 出版时间：March 2004
• 年：2004
• 卷：5
• 期：2
• 页码：295 - 305
• 全文大小：530K
• 年卷期：v.5,no.2(March 2004)
• ISSN：1526-4602

文摘

Various photocurable liquid biodegradable trimethylene carbonate (TMC)-based (co)oligomers were preparedby ring-opening (co)polymerization of TMC with or without L-lactide (LL) using low molecular weightpoly(ethylene glycol) (PEG) (mol wt 200, 600, or 1000) or trimethylolpropane (TMP) as an initiator. Resultant(co)oligomers were pastes, viscous liquids, or liquids at room temperature, depending on the monomercomposition and monomer/initiator ratio. Liquid (co)oligomers were subsequently end-capped with acrylategroups. Upon visible-light irradiation in the presence of camphorquinone as a radical generator, rapid liquid-to-solid transformation occurred to produce photocured solid. The photocuring yield increased withphotoirradiation time, photointensity, and camphorquinone concentration. The photocured polymers derivedfrom low molecular weight PEG (PEG200) and TMP exhibited much reduced hydrolysis potential comparedwith PEG1000-derived polymers in terms of weight loss, water uptake, and swelling depth. Force-distancecurve measurements by nanoindentation using atomic force microscopy clearly showed that Young's moduliof the photocured polymer films decreased with increasing hydrolysis time. Their potential biomedicalapplications are discussed.