A Peptide Motif Recognizing a Polymer Stereoregularity

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• 作者：Takeshi Serizawa ; Toshiki Sawada ; Hisao Matsuno ; Teruhiko Matsubara ; and Toshinori Sato
• 刊名：Journal of the American Chemical Society
• 出版年：2005
• 出版时间：October 12, 2005
• 年：2005
• 卷：127
• 期：40
• 页码：13780 - 13781
• 全文大小：61K
• 年卷期：v.127,no.40(October 12, 2005)
• ISSN：1520-5126

文摘

A combinatorial phage display method was applied to films composed of a stereoregular polymer of methacrylates. The phage clones with selective affinity for isotactic (it) poly(methyl methacrylate) (PMMA) were isolated. Greater amounts of the phage clones bound to it-PMMA, compared to other stereoregular PMMAs. The phage expressing ELWRPTR most strongly bound to the polymer, and the selectivity was also the best. The peptide motif essential for the specific interaction with the stereoregular polymer was revealed.