文摘
An enantioselective intramolecular oxidative cyclization of 4-alkenoic acids was developed. The reaction proceeded via a 蟺-allyl Pd intermediate generated by an allylic C鈥揌 activation to give 纬-lactone derivatives with moderate to good enantioselectivity. Spiro bis(isoxazoline) ligand, SPRIX, was indispensable for this asymmetric transformation.