Organocatalyzed Formal [2 + 2] Cycloaddition of Ketimines with Allenoates: Facile Access to Azetidines with a Chiral Tetrasubstituted Carbon Stereogenic Center

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• 作者：Shinobu Takizawa ; Fernando Arteaga Arteaga ; Yasushi Yoshida ; Michitaka Suzuki ; Hiroaki Sasai
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：August 16, 2013
• 年：2013
• 卷：15
• 期：16
• 页码：4142-4145
• 全文大小：288K
• 年卷期：v.15,no.16(August 16, 2013)
• ISSN：1523-7052

文摘

An enantioselective organocatalyzed aza-MBH-type reaction of ketimines and allenoates has been developed. The present formal [2 + 2] cycloaddition produces highly functionalized azetidines with a chiral tetrasubstituted carbon stereogenic center in good to excellent yields and high enantioselectivities.