Self-Assembly of Maltoheptaose-block-polycaprolactone Copolymers: Carbohydrate-Decorated Nanoparticles with Tunable Morphology and Size in Aqueous Media

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• 作者：Takuya Isono ; Kana Miyachi ; Yusuke Satoh ; Ryosuke Nakamura ; Yao Zhang ; Issei Otsuka ; Kenji Tajima ; Toyoji Kakuchi ; Redouane Borsali ; Toshifumi Satoh
• 刊名：Macromolecules
• 出版年：2016
• 出版时间：June 14, 2016
• 年：2016
• 卷：49
• 期：11
• 页码：4178-4194
• 全文大小：1116K
• 年卷期：0
• ISSN：1520-5835

文摘

This paper describes the systematic investigation into the aqueous self-assembly of a series of block copolymers (BCPs) consisting of maltoheptaose (MH; as the A block) and poly(ε-caprolactone) (PCL; as the B block), i.e., linear AB-type diblock copolymers with varied PCL molecular weights (MH-b-PCL_{(2.5k,3.3k,5k,10k)}), AB_y-type (y = 2, MH-b-(PCL_5k)₂; y = 3, MH-b-(PCL_3.3k)₃), A₂B₂-type ((MH)₂-b-(PCL_5k)₂), and A_xB-type miktoarm star polymers (x = 2, (MH)₂-b-PCL_10k; x = 3, (MH)₃-b-PCL_10k), which had been precisely synthesized via the combination of the living ring-opening polymerization and click reaction. Under similar conditions, the nanoprecipitation method was employed to self-assemble them in an aqueous medium. Imaging and dynamic light scattering techniques indicated the successful formation of the carbohydrate-decorated nanoparticles via self-assembly. The MH-b-PCLs formed regular core–shell micellar nanoparticles with the hydrodynamic radius (R_h) of 17–43 nm. MH-b-(PCL_5k)₂ and MH-b-(PCL_3.3k)₃, which have an N_PCL comparable to MH-b-PCL_10k, were found to form large compound micelles with relatively large radii (R_h of 49 and 56 nm, respectively). On the other hand, (MH)₂-b-(PCL_5k)₂, (MH)₂-b-PCL_10k, and (MH)₃-b-PCL_10k predominantly formed the regular core–shell micellar nanoparticles (R_h = 29–39 nm) with a size smaller than that of MH-b-PCL_10k (R_h = 43 nm).