Stereocontrolled Synthesis of (+)-Methoxyphenylkainic Acid and (+)-Phenylkainic Acid

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• 作者：Takumi Higashi ; Yoichiro Isobe ; Hitoshi Ouchi ; Hiroto Suzuki ; Yuko Okazaki ; Tomohiro Asakawa ; Takumi Furuta ; Toshiyuki Wakimoto ; Toshiyuki Kan
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：March 4, 2011
• 年：2011
• 卷：13
• 期：5
• 页码：1089-1091
• 全文大小：777K
• 年卷期：v.13,no.5(March 4, 2011)
• ISSN：1523-7052

文摘

The efficient total syntheses of (+)-methoxyphenylkainic acid (3) and (+)-phenylkainic acid (4) were achieved using a rhodium carbenoid-mediated intermolecular C鈭扝 insertion reaction. Complete stereoselective construction of the kainoid skeleton was accomplished by utilizing the stereochemistry at the C-4 position as a pivotal stereogenic center.