Novel Effects of a Single Administration of Ferulic Acid on the Regulation of Blood Pressure and the Hepatic Lipid Metabolic Profile in Stroke-Prone Spontaneously Hypertensive Rats

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• 作者：Ardiansyah ; Yusuke Ohsaki ; Hitoshi Shirakawa ; Takuya Koseki ; Michio Komai
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2008
• 出版时间：April 23, 2008
• 年：2008
• 卷：56
• 期：8
• 页码：2825 - 2830
• 全文大小：139K
• 年卷期：v.56,no.8(April 23, 2008)
• ISSN：1520-5118

文摘

We studied the effects of a single oral administration of ferulic acid (FA) on the blood pressure (BP) and lipid profile in stroke-prone spontaneously hypertensive rats (SHRSP). Male 12-week-old SHRSP were administered FA (9.5 mg/kg of body weight) and distilled water as the control (C) (1 mL) via a gastric tube. The hypotensive effect of FA was observed at the lowest value after 2 h administration. A decrease in the angiotensin-1-converting enzyme (ACE) activity in the plasma corresponded well with the reduction of BP. Plasma total cholesterol and triglyceride levels were lower after 2 h administration. The mRNA expression of genes involved in lipid and drug metabolism was downregulated in the FA group. These results suggest that oral administration of FA appears beneficial in improving hypertension and hyperlipidemia.