Multipixel Techniques for Frequency-Domain Photon Migration Imaging

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• 作者：Jeffery S. Reynolds ; Tamara L. Troy ; and Eva M. Sevick-Muraca
• 刊名：Biotechnology Progress
• 出版年：1997
• 出版时间：October 1997
• 年：1997
• 卷：13
• 期：5
• 页码：669 - 680
• 全文大小：671K
• 年卷期：v.13,no.5(October 1997)
• ISSN：1520-6033

文摘

The ability to map interior optical properties of a highly scatteringmedium fromexterior measurements of light propagation is afforded by opticaltomography. In thiscommunication, we describe the problem of optical tomography, thetechniques ofphoton migration measurements necessary to accomplish it, and thedevelopment ofmultipixel measurements for rapid collection of optical signals.These multipixelmeasurements are shown to provide detection of contrast owing to theoptical propertiesof absorption and fluorescence associated with dye-ladenheterogeneities embeddedin a tissue-like scattering medium. From these rapid measurements,successfulreconstruction of an interior optical property map may now be possiblewith clinicallyrealistic data acquisition times. Applications for the technologyarise for biomedicaloptical imaging for the in vivo detection of disease and thediagnosis of tissue (bio-)chemistry.