First Total Synthesis and Stereochemical Revision of Laxaphycin B and Its Extension to Lyngbyacyclamide A

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• 作者：France Boyaud ; Zahia Mahiout ; Christine Lenoir ; Shoubin Tang ; Joanna Wdzieczak-Bakala ; Anne Witczak ; Isabelle Bonnard ; Bernard Banaigs ; Tao Ye ; Nicolas Inguimbert
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：August 2, 2013
• 年：2013
• 卷：15
• 期：15
• 页码：3898-3901
• 全文大小：257K
• 年卷期：v.15,no.15(August 2, 2013)
• ISSN：1523-7052

文摘

The first total synthesis of laxaphycin B was accomplished through stepwise automated Solid Phase Peptide Synthesis (SPPS), leading to the structural revision of its stereochemistry especially with regard to the configuration of one of the two 3-hydroxyleucines of this cyclic dodecapeptide of marine origin. The analogous Lyngbyacyclamide A was obtained by an extension of this synthesis.