Structural Diversity of New C13-Polyketides Produced by Chaetomium mollipilium Cultivated in the Presence of a NAD+-Dependent Histone Deacetylase Inhibitor

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• 作者：Teigo Asai ; Shuntaro Morita ; Naoki Shirata ; Tohru Taniguchi ; Kenji Monde ; Hiroaki Sakurai ; Tomoji Ozeki ; Yoshiteru Oshima
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：November 2, 2012
• 年：2012
• 卷：14
• 期：21
• 页码：5456-5459
• 全文大小：290K
• 年卷期：v.14,no.21(November 2, 2012)
• ISSN：1523-7052

文摘

Cultivation of Chaetomium mollipilium with nicotinamide, a NAD⁺-dependent HDAC inhibitor, stimulated its secondary metabolism, leading to the isolation of structurally diverse new C₁₃-polyketides, mollipilin A鈥揈 (1鈥?b>5) as well as two known compounds (6 and 7). Spectroscopic methods, X-ray single crystal diffraction analysis, and VCD elucidated the absolute configurations of structures 1鈥?b>6, and plausible biosynthetic pathways for 1鈥?b>7 were proposed based on structural relationships. Mollipilins A (1) and B (2) exhibited moderate growth inhibitory effects on HCT-116 cells.