Acetylated Sesterterpenes from the Great Barrier Reef Sponge Luffariella variabilis
详细信息 查看全文
- 作者：Piers Ettinger-Epstein ; Cherie A. Motti ; Rocky de Nys ; Anthony D. Wright ; Christopher N. Battershill ; Dianne M. Tapiolas
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：April 2007
- 年：2007
- 卷：70
- 期：4
- 页码：648 - 651
- 全文大小：51K
- 年卷期：v.70,no.4(April 2007)
- ISSN：1520-6025
文摘
Chemical investigation of the sponge Luffariella variabilis collected from the Palm Island group of the Great BarrierReef, Australia, yielded three new acetylated compounds, 25-acetoxyluffariellin A (1), 25-acetoxyluffariellin B (2), and25-acetoxyseco-manoalide (3). The structures of the new compounds were elucidated on the basis of interpretation oftheir spectroscopic data. The known metabolites manoalide (4), seco-manoalide (5), luffariellin A (8), and manoalidemonoacetate (10) were also isolated. The new acetylated compounds (1-3) were labile in the sponge tissue whensamples were allowed to thaw prior to extraction, but were stable once isolated. Sponge samples that were completelythawed contained only hydroxylated compounds (alcohols). This finding supported the deduction that the acetylatedcompounds are being enzymatically transformed and/or degraded.