Comosusols A鈭扗 and Comosone A: Cytotoxic Compounds from the Brown Alga Sporochnus comosus

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• 作者：Simon P. B. Ovenden ; Jonathan L. Nielson ; Catherine H. Liptrot ; Richard H. Willis ; Anthony D. Wright ; Cherie A. Motti ; Dianne M. Tapiolas
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：April 25, 2011
• 年：2011
• 卷：74
• 期：4
• 页码：739-743
• 全文大小：742K
• 年卷期：v.74,no.4(April 25, 2011)
• ISSN：1520-6025

文摘

Bioassay-guided fractionation of extracts of the brown alga Sporochnus comosus led to the isolation of five new compounds, comosusols A鈭扗 (3鈭?b>6) and comosone A (7). The structures of all isolated compounds were elucidated using standard one- and two-dimensional NMR techniques, as well as comparison with literature values. The cytotoxic activity of all compounds was investigated against a panel of human tumor and mammalian cell lines. These assays found eight of the nine compounds had GI₅₀ values in the 8鈭?3 渭M range.