Sesquiterpene Benzoxazoles and Sesquiterpene Quinones from the Marine Sponge Dactylospongia elegans

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• 作者：Simon P. B. Ovenden ; Jonathan L. Nielson ; Catherine H. Liptrot ; Richard H. Willis ; Dianne M. Tapiolas ; Anthony D. Wright ; Cherie A. Motti
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：January 28, 2011
• 年：2011
• 卷：74
• 期：1
• 页码：65-68
• 全文大小：124K
• 年卷期：v.74,no.1(January 28, 2011)
• ISSN：1520-6025

文摘

A new sesquiterpene benzoxazole, nakijinol B (3), its acetylated derivative, nakijinol B diacetate (6), and two new sesquiterpene quinones, smenospongines B (4) and C (5), were isolated from the methanol extract of the marine sponge Dactylospongia elegans. Also isolated were the known compounds dactyloquinone B and a 1:1 mixture of ilimaquinone and 5-epi-ilimaquinone. Their structures were determined on the basis of spectroscopic analyses and comparison with literature data. The isolated compounds were assessed for their cytotoxicity against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a normal mammalian cell line (CHO-K1). All compounds were found to have activities in the range 1.8鈭?6 渭M and lacked selectivity for tumor versus normal cell lines.