Organosilicon Molecules with Medicinal Applications

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• 作者：Annaliese K. Franz ; Sean O. Wilson
• 刊名：Journal of Medicinal Chemistry
• 出版年：2013
• 出版时间：January 24, 2013
• 年：2013
• 卷：56
• 期：2
• 页码：388-405
• 全文大小：949K
• 年卷期：v.56,no.2(January 24, 2013)
• ISSN：1520-4804

文摘

The incorporation of silicon and synthesis of organosilicon small molecules provide unique opportunities for medicinal applications. The biological investigation of organosilicon small molecules is particularly interesting because of differences in their chemical properties that can contribute to enhanced potency and improved pharmacological attributes. Applications such as inhibitor design, imaging, drug release technology, and mapping inhibitor binding are discussed.