Ruthenium-catalyzed [2 + 2 + 1] Cocyclization of Isocyanates, Alkynes, and CO Enables the Rapid Synthesis of Polysubstituted Maleimides
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- 作者：Teruyuki Kondo ; Masato Nomura ; Yasuyuki Ura ; Kenji Wada ; Take-aki Mitsudo
- 刊名：Journal of the American Chemical Society
- 出版年：2006
- 出版时间：November 22, 2006
- 年：2006
- 卷：128
- 期：46
- 页码：14816 - 14817
- 全文大小：74K
- 年卷期：v.128,no.46(November 22, 2006)
- ISSN：1520-5126
文摘
Intermolecular [2 + 2 + 1] cocyclization of isocyanates, alkynes, and CO (1 atm) proceeded smoothly in the presence of a catalytic amount of Ru3(CO)12 (3.3 mol %) in mesitylene at 130 
C for 3~42 h to give a variety of polysubstituted maleimides in excellent yields with high selectivity. The reaction may involve an azaruthenacyclopentenone intermediate derived from oxidative cyclization of an isocyanate and an alkyne on an active ruthenium species.
C for 3~42 h to give a variety of polysubstituted maleimides in excellent yields with high selectivity. The reaction may involve an azaruthenacyclopentenone intermediate derived from oxidative cyclization of an isocyanate and an alkyne on an active ruthenium species.