Synthesis of 1,2,3,6-Tetrahydropyridines via Aminophosphate Enabled Anionic Cascade and Acid Catalyzed Cyclization Approaches
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- 作者：Pradipta Das ; Jon T. Njardarson
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：August 21, 2015
- 年：2015
- 卷：17
- 期：16
- 页码：4030-4033
- 全文大小：403K
- ISSN：1523-7052
文摘
Two new approaches for forming 1,2,3,6-tetrahydropyridines are reported. Both reactions employ a strategic phosphate substituent on the nitrogen atom. In the presence of an additional phosphate substituent (X = P = O(OEt)2) an anionic cascade can by triggered upon treatment with base. Alternatively, when X = H the same 1,2,3,6-tetrahydropyridine product can be accessed via an acid catalyzed cyclization.