Implementation on Pilot-Plant Scale of the Titanocene-Catalyzed Reduction of a Lactone with Poly(methylhydrosiloxane)

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• 作者：Dominique Depr&#xe9 ; Andr&#xe1 ; s Horv&#xe1 ; th ; Walter Snissaert ; Leo Van Den Bergh ; Wim Dermaut
• 刊名：Organic Process Research & Development
• 出版年：2008
• 出版时间：January 2008
• 年：2008
• 卷：12
• 期：1
• 页码：96 - 100
• 全文大小：678K
• 年卷期：v.12,no.1(January 2008)
• ISSN：1520-586X

文摘

The titanocene-catalyzed reduction of the lactone 1 into the lactol 2 was studied. This process uses poly(methylhydrosiloxane) as stoichiometric reductant. Thermodynamic and safety data was collected in order to develop a reliable, safe and scalable process that was successfully implemented in the pilot plant. Using this new process, the target lactol was obtained on 30-kg scale with better yield and purity than with a former process using DIBALH, while decreasing the amount of waste.