Bougainvinones A–H, Peltogynoids from the Stem Bark of Purple Bougainvillea spectabilis and Their Cytotoxic Activity

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• 作者：Lien T. M. Do ; Thammarat Aree ; Pongpun Siripong ; Tuyen N. K. Pham ; Phung K. P. Nguyen ; Santi Tip-pyang
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：April 22, 2016
• 年：2016
• 卷：79
• 期：4
• 页码：939-945
• 全文大小：293K
• 年卷期：0
• ISSN：1520-6025

文摘

Eight new peltogynoids, named bougainvinones A–H (1–8), were obtained from the stem bark of Bougainvillea spectabilis. Their structures were elucidated by means of physical data (1D and 2D NMR, HRESIMS) and single-crystal X-ray crystallographic analyses. The peltogynoids, a rare type of modified flavonoids, are reported for the first time from this species of the genus Bougainvillea. All isolated compounds were evaluated for their cytotoxic effects against five cancer cell lines including KB, Hela S-3, HT-29, MCF-7, and HepG2. Among them, compound 7 showed cytotoxicity against five cancer cell lines with IC₅₀ values in the 7.4–9.7 μM range, and compounds 2 and 3 exhibited cytotoxicity against the KB cell line with IC₅₀ values of 6.6 and 9.0 μM.