Synthesis of N-Aryl and N-Alkyl Anthranilic Acids via SNAr Reaction of Unprotected 2-Fluoro- and 2-Methoxybenzoic Acids by Lithioamides

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• 作者：Mickal Belaud-Rotureau ; Tin Thanh Le ; Thi Huong Thu Phan ; Thi Huu Nguyen ; Regadia Aissaoui ; Frdric Gohier ; Acha Derdour ; Arnaud Nourry ; Anne-Sophie Castanet ; Kim Phi Phung Nguyen ; Jacques Mortier
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：May 21, 2010
• 年：2010
• 卷：12
• 期：10
• 页码：2406-2409
• 全文大小：169K
• 年卷期：v.12,no.10(May 21, 2010)
• ISSN：1523-7052

文摘

Substitution of the fluoro or methoxy group in unprotected 2-fluoro- and 2-methoxybenzoic acids to afford N-aryl and N-alkyl anthranilic acids occurs upon reaction with lithioamides under mild conditions in the absence of a metal catalyst.