Raman Dye-Labeled Nanoparticle Probes for Proteins

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• 作者：Y. Charles Cao ; Rongchao Jin ; Jwa-Min Nam ; C. Shad Thaxton ; and Chad A. Mirkin
• 刊名：Journal of the American Chemical Society
• 出版年：2003
• 出版时间：December 3, 2003
• 年：2003
• 卷：125
• 期：48
• 页码：14676 - 14677
• 全文大小：91K
• 年卷期：v.125,no.48(December 3, 2003)
• ISSN：1520-5126

文摘

In this paper, we demonstrate how one can chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities and use these probes, coupled with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed screening of protein-small molecule interactions and protein-protein interactions in a protein microarray format.