Protein-Induced Supramolecular Disassembly of Amphiphilic Polypeptide Nanoassemblies

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• 作者：Mijanur Rahaman Molla ; Priyaa Prasad ; S. Thayumanavan
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：June 17, 2015
• 年：2015
• 卷：137
• 期：23
• 页码：7286-7289
• 全文大小：323K
• ISSN：1520-5126

文摘

Mimicking noncovalent interaction based processes in nature has been an important goal of supramolecular chemistry. Here, we report on amphiphilic polypeptides that self-assemble to form nanoscale supramolecular assemblies and are programmed to disassemble in response to a specific protein. Benzenesulfonamide and carbonic anhydrase have been chosen as the ligand and protein, respectively, to demonstrate this possibility. Since the amphiphilic nanoassembly sequesters hydrophobic guest molecules, the protein-specific disassembly event provides a protein-sensitive molecular release as well. We envision that the binding induced disassembly and guest release might open up new opportunities for the next generation of supramolecular assemblies for protein-specific delivery and diagnostics.