Sorting of Enhanced Reference Raman Spectra of a Single Amino Acid Molecule

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• 作者：Thibault Brul茅 ; H茅l猫ne Yockell-Leli猫vre ; Alexandre Bouh茅lier ; J茅r茅mie Margueritat ; Laurent Markey ; Aymeric Leray ; Alain Dereux ; Eric Finot
• 刊名：Journal of Physical Chemistry C
• 出版年：2014
• 出版时间：August 7, 2014
• 年：2014
• 卷：118
• 期：31
• 页码：17975-17982
• 全文大小：439K
• ISSN：1932-7455

文摘

In this contribution, we report the identification of the principal reference Raman spectra of a single cystein molecule. To that purpose, we design an active Surface Enhanced Raman Spectroscopy (SERS) template based on surfactant-less Chebyshev nanoparticles operating in a microfluidic platform. A principal component analysis is obtained from fluctuating spectra to sort the reference spectra of cystein. The assignment of Raman bands brings new insight into the conformation of an amino acid adsorbed onto gold nanoparticle.