Visible-Light-Mediated Synthesis of Amidyl Radicals: Transition-Metal-Free Hydroamination and N-Arylation Reactions

详细信息    查看全文

• 作者：Jacob Davies ; Thomas D. Svejstrup ; Daniel Fernandez Reina ; Nadeem S. Sheikh ; Daniele Leonori
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：July 6, 2016
• 年：2016
• 卷：138
• 期：26
• 页码：8092-8095
• 全文大小：438K
• 年卷期：0
• ISSN：1520-5126

文摘

The development of photoredox reactions of aryloxy-amides for the generation of amidyl radicals and their use in hydroamination–cyclization and N-arylation reactions is reported. Owing to the ease of single-electron-transfer reduction of the aryloxy-amides, the organic dye eosin Y was used as the photoredox catalyst, which results in fully transition-metal-free processes. These transformations exhibit a broad scope, are tolerant to several important functionalities, and have been used in the late-stage modification of complex and high-value N-containing molecules.