Lepidotol A from Mesua lepidota Inhibits Inflammatory and Immune Mediators in Human Endothelial Cells
详细信息 查看全文
- 作者：Caroline Rouger ; S茅verine Derbr茅 ; B茅atrice Charreau ; Ang茅lique Pabois ; Thomas Cauchy ; Marc Litaudon ; Khalijah Awang ; Pascal Richomme
- 刊名：Journal of Natural Products
- 出版年：2015
- 出版时间：September 25, 2015
- 年：2015
- 卷：78
- 期：9
- 页码：2187-2197
- 全文大小：525K
- ISSN：1520-6025
文摘
Phytochemical investigation on the fruits of Mesua lepidota (Calophyllaceae) led to the isolation of seven new phenylcoumarin derivatives named lepidotols A鈥揈 (1鈥?b>5) and lepidotins A and B (6, 7). These structures were elucidated by spectroscopic and spectrometric methods including UV, NMR, and HRMS. Lepidotol A (1), the major compound, was evaluated for its inhibitory effect on inflammation and immunity using endothelial cell-based cellular assays. At 10 渭M, 1 exhibited an anti-inflammatory activity, with a significant inhibition of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 expression induced by tumor necrosis factor-伪. Lepidotol A also showed a mild immunosuppressive effect, with inhibition of the major histocompatibility complex molecules, namely, human leukocyte antigen (HLA)-DR and HLA-E.