Totopotensamides, Polyketide鈥揅yclic Peptide Hybrids from a Mollusk-Associated Bacterium Streptomyces sp.
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- 作者：Zhenjian Lin ; Malem Flores ; Imelda Forteza ; Niel M. Henriksen ; Gisela P. Concepcion ; Gary Rosenberg ; Margo G. Haygood ; Baldomero M. Olivera ; Alan R. Light ; Thomas E. Cheatham ; III ; Eric W. Schmidt
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：April 27, 2012
- 年：2012
- 卷：75
- 期：4
- 页码：644-649
- 全文大小：289K
- 年卷期：v.75,no.4(April 27, 2012)
- ISSN：1520-6025
文摘
Two new compounds, the peptide鈥損olyketide glycoside totopotensamide A (1) and its aglycone totopotensamide B (2), were isolated from a Streptomyces sp. cultivated from the gastropod mollusk Lienardia totopotens collected in the Philippines. The compounds contain a previously undescribed polyketide component, a novel 2,3-diaminobutyric acid-containing macrolactam, and a new amino acid, 4-chloro-5,7-dihydroxy-6-methylphenylglycine. The application of Marfey鈥檚 method to phenylglycine derivatives was explored using quantum mechanical calculations and NMR.