Gersemiols A–C and Eunicellol A, Diterpenoids from the Arctic Soft Coral Gersemia fruticosa

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• 作者：Carlos Angulo-Preckler ; Grégory Genta-Jouve ; Nipun Mahajan ; Mercedes de la Cruz ; Nuria de Pedro ; Fernando Reyes ; Katrin Iken ; Conxita Avila ; Olivier P. Thomas
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：April 22, 2016
• 年：2016
• 卷：79
• 期：4
• 页码：1132-1136
• 全文大小：267K
• 年卷期：0
• ISSN：1520-6025

文摘

Three new diterpenes named gersemiols A–C (1–3) and a new eunicellane diterpene, eunicellol A (4), have been isolated together with the known sesquiterpene (+)-α-muurolene (5) from the Arctic soft coral Gersemia fruticosa. The name gersemiane was assigned to the rare and unnamed diterpene skeleton of compounds 1–3 corresponding to 4-isopropyl-1,5,8a-trimethyltetradecahydrophenanthrene. The chemical structures were elucidated on the basis of extensive spectroscopic analysis (HR-ESIMS, 1D and 2D NMR) as well as coupling constant calculations for the determination of the relative configurations. All compounds were tested for their antimicrobial activity against several bacteria and fungi and eunicellol A was found to exhibit moderate and selective antibacterial activity.