Synthetic Protocol toward Fused Pyrazolone Derivatives via a Michael Addition and Reductive Ring Closing Strategy

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• 作者：Nikita Parekh ; Joice Thomas ; Jubi John ; Radhika Kusurkar ; Wim M. De Borggraeve ; Wim Dehaen
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：June 6, 2014
• 年：2014
• 卷：79
• 期：11
• 页码：5338-5344
• 全文大小：367K
• 年卷期：v.79,no.11(June 6, 2014)
• ISSN：1520-6904

文摘

A new class of pyrazolo[3,4-c]pyridine-3,7-dione and pyrazolo[3,4-d]azepine-3,7-dione scaffolds was synthesized via a Michael addition and reductive cyclization strategy. These fused heterocycles were accessed from simple starting materials such as nitroolefins and 3-ethoxycarbonyl(methylene)pyrazoline-5-one. The pyrazolo-fused heterocycles were obtained in good overall yields.