Stepwise Self-Assembly of DNA Tile Lattices Using dsDNA Bridges

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• 作者：Sung Ha Park ; Gleb Finkelstein ; Thomas H. LaBean
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：January 9, 2008
• 年：2008
• 卷：130
• 期：1
• 页码：40 - 41
• 全文大小：401K
• 年卷期：v.130,no.1(January 9, 2008)
• ISSN：1520-5126

文摘

The simple helical motif of double-strand DNA (dsDNA) has typically been judged to be uninteresting for assembly in DNA-based nanotechnology applications. In this letter, we demonstrate construction of superstructures consisting of heterogeneous DNA motifs using dsDNA in conjunction with more complex, cross-tile building blocks. Incorporation of dsDNA bridges in stepwise assembly processes can be used for controlling length and directionality of superstructures and is analogous to the "reprogramming" of sticky-ends displayed on the DNA tiles. Two distinct self-assembled DNA lattices, fixed-size nanoarrays, and extended 2D crystals of nanotracks with nanobridges, are constructed and visualized by high-resolution, liquid-phase atomic force microscopy.