Bioactive Diterpenoid Containing a Reversible 鈥淪pring-Loaded鈥?(E,Z)-Dieneone Michael Acceptor
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- 作者：Prasoon Gupta ; Upasana Sharma ; Thomas C. Schulz ; Eric S. Sherrer ; Amanda B. McLean ; Allan J. Robins ; Lyndon M. West
- 刊名：Organic Letters
- 出版年：2011
- 出版时间：August 5, 2011
- 年：2011
- 卷：13
- 期：15
- 页码：3920-3923
- 全文大小：703K
- 年卷期：v.13,no.15(August 5, 2011)
- ISSN：1523-7052
文摘
Three new briarane diterpenoids, briareolate esters L鈥揘 (1鈥?b>3), have been isolated from a gorgonian Briareum asbestinum. Briareolate esters L (1) and M (2) are the first natural products possessing a 10-membered macrocyclic ring with a (E,Z)-dieneone and exhibit growth inhibition activity against both human embryonic stem cells (BG02) and a pancreatic cancer cell line (BxPC-3). Briareolate ester L (1) was found to contain a 鈥渟pring-loaded鈥?(E,Z)-dieneone Michael acceptor group that can form a reversible covalent bond to model sulfur-based nucleophiles.