Optimized Synthesis of L-m-Tyrosine Suitable for Chemical Scale-Up
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- 作者：Cara E. Humphrey ; Markus Furegati ; Kurt Laumen ; Luigi La Vecchia ; Thomas Leutert ; J. Constanze D. Mü ; ller-Hartwieg ; Markus Vö ; gtle
- 刊名：Organic Process Research & Development
- 出版年：2007
- 出版时间：November 2007
- 年：2007
- 卷：11
- 期：6
- 页码：1069 - 1075
- 全文大小：141K
- 年卷期：v.11,no.6(November 2007)
- ISSN：1520-586X
文摘
This paper demonstrates how L-m-tyrosine 1 can be synthesized on larger-scale via enzyme-catalyzed kinetic resolution of N-acyl m-tyrosine methyl ester 4. N-Acyl m-tyrosine methyl ester 4 was prepared by a modification of Erlenmeyer’s azalactone synthesis followed by hydrogenation of the resultant dehydroamino acid 12. The optimized four-step synthesis utilizes cheap and readily available starting materials and circumvents difficult purification protocols.