Complementary Detection of Prostate-Specific Antigen Using In2O3 Nanowires and Carbon Nanotubes

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• 作者：Chao Li ; Marco Curreli ; Henry Lin ; Bo Lei ; F. N. Ishikawa ; Ram Datar ; Richard J. Cote ; Mark E. Thompson ; and Chongwu Zhou
• 刊名：Journal of the American Chemical Society
• 出版年：2005
• 出版时间：September 14, 2005
• 年：2005
• 卷：127
• 期：36
• 页码：12484 - 12485
• 全文大小：97K
• 年卷期：v.127,no.36(September 14, 2005)
• ISSN：1520-5126

文摘

We report complementary detection of prostate-specific antigen (PSA) using n-type In₂O₃ nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In₂O₃ NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In₂O₃ NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.