Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products
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- 作者：Dennis X. Hu ; David M. Withall ; Gregory L. Challis ; Regan J. Thomson
- 刊名：Chemical Reviews
- 出版年：2016
- 出版时间：July 27, 2016
- 年：2016
- 卷：116
- 期：14
- 页码：7818-7853
- 全文大小：2577K
- 年卷期：0
- ISSN：1520-6890
文摘
The prodiginine family of bacterial alkaloids is a diverse set of heterocyclic natural products that have likely been known to man since antiquity. In more recent times, these alkaloids have been discovered to span a wide range of chemical structures that possess a number of interesting biological activities. This review provides a comprehensive overview of research undertaken toward the isolation and structural elucidation of the prodiginine family of natural products. Additionally, research toward chemical synthesis of the prodiginine alkaloids over the last several decades is extensively reviewed. Finally, the current, evidence-based understanding of the various biosynthetic pathways employed by bacteria to produce prodiginine alkaloids is summarized.