Synthesis of tert-Butyl 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate

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• 作者：Marvin J. Meyers ; Inouk Muizebelt ; Jim van Wiltenburg ; David L. Brown ; Atli Thorarensen
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：August 20, 2009
• 年：2009
• 卷：11
• 期：16
• 页码：3523-3525
• 全文大小：163K
• 年卷期：v.11,no.16(August 20, 2009)
• ISSN：1523-7052

文摘

Two efficient and scaleable synthetic routes to previously unknown bifunctional tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate are described. This compound and related intermediates described herein are useful for further selective derivation on the azetidine and cyclobutane rings providing a convenient entry point to novel compounds accessing chemical space complementary to piperidine ring systems.