Single Molecule Analysis of Self-Assembly Supramolecular Oligomers in Solution

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• 作者：Fu-Na Meng ; Xuyang Yao ; Junji ZhangYi-Lun Ying ; He Tian
• 刊名：ACS Sensor
• 出版年：2016
• 出版时间：December 23, 2016
• 年：2016
• 卷：1
• 期：12
• 页码：1398-1402
• 全文大小：491K
• ISSN：2379-3694

文摘

The supramolecular oligomers play an important role because their preorganized precise structures lead to a well-defined structure–property relationship. Here, we employed an α-hemolysin nanopore as a single molecule tool to investigate the self-assembly supramolecular oligomers of bis(p-sulfonatocalix[4]arene) (bisSC4) and bis(methylviologen) (bisMV⁴⁺). The self-assembly of supramolecular oligomers could be dynamic monitored at single molecule level. The association constant between bisSC4 and bisMV⁴⁺ was calculated based on current blockage frequencies at the single molecule level. This work provides a complementary method to characterize the self-assembly oligomers with low molecular weight in solution.