Organocatalyzed Enantioselective Mannich Reaction of Pyrazoleamides with Isatin-Derived Ketimines

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• 作者：Tian-Ze Li ; Xi-Bo Wang ; Feng Sha ; Xin-Yan Wu
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：May 16, 2014
• 年：2014
• 卷：79
• 期：10
• 页码：4332-4339
• 全文大小：336K
• 年卷期：v.79,no.10(May 16, 2014)
• ISSN：1520-6904

文摘

The first organocatalytic enantioselective Mannich reaction of pyrazoleamides with isatin-derived N-Boc ketimines has been developed to afford 2-oxindole-based chiral 尾-amino amides in good yields (84鈥?7%) with excellent diastereo- and enantioselectivities (up to 99:1 dr and >99% ee).