文摘
The solubilities of rutaecarpine in 12 organic solvents (dichloromethane, ethyl acetate, acetone, trichloromethane, ethoxyethane, butyl alcohol, isopropyl alcohol, ethyl alcohol, methyl alcohol, cyclohexane, hexane, and pentane) were measured over the temperature range of (283.2 to 323.2) K. The solubilities of rutaecarpine in selected organic solvents increase with the increasing of the temperature and were correlated by the modified Apelblat equation and a simplified thermodynamic equation. The dissolution enthalpy and entropy of rutaecarpine in these solvents were calculated using the van鈥檛 Hoff equation. The results showed that the dissolution process was endothermic and entropy-driven.