Biodegradable Amphiphilic Triblock Copolymer Bearing Pendant Glucose Residues: Preparation and Specific Interaction with Concanavalin A Molecules
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- 作者：Changhai Lu ; Xuesi Chen ; Zhigang Xie ; Tiancheng Lu ; Xin Wang ; Jia Ma ; and Xiabin Jing
- 刊名：Biomacromolecules
- 出版年：2006
- 出版时间：June 2006
- 年：2006
- 卷：7
- 期：6
- 页码：1806 - 1810
- 全文大小：294K
- 年卷期：v.7,no.6(June 2006)
- ISSN：1526-4602
文摘
A novel biodegradable amphiphilic block copolymer PLGG-PEG-PLGG bearing pendant glucose residues issuccessfully prepared by the coupling reaction of 3-(2-aminoethylthio)propyl-
-D-glucopyranoside with the pendantcarboxyl groups of PLGG-PEG-PLGG in the presence of N,N'-carbonyldiimidazole. The polymer PLGG-PEG-PLGG, i.e., poly{(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}-block-poly(ethylene glycol)-block- poly{(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}, is prepared by ring-opening copolymerization of L-lactide(LLA) with (3s)-benzoxylcarbonylethylmorpholine-2,5-dione (BEMD) in the presence of dihydroxyl PEG withmolecular weight of 2000 as macroinitiator and Sn(Oct)2 as catalyst, and then by catalytic hydrogenation. Theglucose-grafted copolymer shows a lower degree of cytotoxicity to ECV-304 cells and improved specific recognitionand binding with Concanavalin A (Con A). Therefore, this kind of glucose-grafted copolymer may find biomedicalapplications.
-D-glucopyranoside with the pendantcarboxyl groups of PLGG-PEG-PLGG in the presence of N,N'-carbonyldiimidazole. The polymer PLGG-PEG-PLGG, i.e., poly{(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}-block-poly(ethylene glycol)-block- poly{(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}, is prepared by ring-opening copolymerization of L-lactide(LLA) with (3s)-benzoxylcarbonylethylmorpholine-2,5-dione (BEMD) in the presence of dihydroxyl PEG withmolecular weight of 2000 as macroinitiator and Sn(Oct)2 as catalyst, and then by catalytic hydrogenation. Theglucose-grafted copolymer shows a lower degree of cytotoxicity to ECV-304 cells and improved specific recognitionand binding with Concanavalin A (Con A). Therefore, this kind of glucose-grafted copolymer may find biomedicalapplications.