Structure and Biosynthesis of the Antibiotic Bottromycin D

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• 作者：Yanpeng Hou ; Ma. Diarey B. Tianero ; Jason C. Kwan ; Thomas P. Wyche ; Cole R. Michel ; Gregory A. Ellis ; Emmanuel Vazquez-Rivera ; Doug R. Braun ; Warren E. Rose ; Eric W. Schmidt ; Tim S. Bugni
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：October 5, 2012
• 年：2012
• 卷：14
• 期：19
• 页码：5050-5053
• 全文大小：186K
• 年卷期：v.14,no.19(October 5, 2012)
• ISSN：1523-7052

文摘

Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based metabolomics were applied to analyze extracts of 50 Streptomyes spp. Using this methodology, we discovered bottromycin D and used whole genome sequencing to determine its biosynthesis by a ribosomal pathway.