Nonenzymatic Electrochemical Detection of Glucose Based on Palladium−Single-Walled Carbon Nanotube Hybrid Nanostructures

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• 作者：Ling Meng ; Juan Jin ; Gaixiu Yang ; Tianhong Lu ; Hui Zhang ; Chenxin Cai
• 刊名：Analytical Chemistry
• 出版年：2009
• 出版时间：September 1, 2009
• 年：2009
• 卷：81
• 期：17
• 页码：7271-7280
• 全文大小：293K
• 年卷期：v.81,no.17(September 1, 2009)
• ISSN：1520-6882

文摘

A new electrocatalyst, palladium nanoparticle−single-walled carbon nanotube (Pd−SWNTs) hybrid nanostructure, for the nonenzymatic oxidation of glucose was developed and characterized by X-ray diffraction (XRD) and the transmission electron microscope (TEM). The hybrid nanostructures were prepared by depositing palladium nanoparticles with average diameters of 4−5 nm on the surface of single-walled carbon nanotubes (SWNTs) via chemical reduction of the precursor (Pd²⁺). The electrocatalyst showed good electrocatalytic activity toward the oxidation of glucose in the neutral phosphate buffer solution (PBS, pH 7.4) even in the presence of a high concentration of chloride ions. A nonenzymatic amperometric glucose sensor was developed with the use of the Pd−SWNT nanostructure as an electrocatalyst. The sensor had good electrocatalytic activity toward oxidation of glucose and exhibited a rapid response (ca.3 s), a low detection limit (0.2 ± 0.05 μM), a wide and useful linear range (0.5−17 mM), and high sensitivity (160 μA mM⁻¹ cm⁻²) as well as good stability and repeatability. In addition, the common interfering species, such as ascorbic acid, uric acid, 4-acetamidophenol, 3,4-dihydroxyphenylacetic acid, and so forth did not cause any interference due to the use of a low detection potential (−0.35 V vs SCE). The sensor can also be used for quantification of the concentration of glucose in real clinical samples. Therefore, this work has demonstrated a simple and effective sensing platform for nonenzymatic detection of glucose.