Copper-Catalyzed Oxidative Cross-Coupling of N,N-Dimethylanilines with Heteroarenes under Molecular Oxygen

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• 作者：Lehao Huang ; Tianmin Niu ; Jun Wu ; Yuhong Zhang
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：March 18, 2011
• 年：2011
• 卷：76
• 期：6
• 页码：1759-1766
• 全文大小：1022K
• 年卷期：v.76,no.6(March 18, 2011)
• ISSN：1520-6904

文摘

Nitrogen-containing heterocyclic compounds are important motifs of pharmaceuticals and functional materials, and there has been a growing interest in new synthetic methods for their preparation. In this paper, we report a direct cross-coupling reaction of heteroarenes with N,N-dimethylanilines in the presence of copper catalyst. Oxygen and/or air are successfully used as the oxidant, which is of great importance to the industrialized economies. The reaction is compatible with a wide range of heterocycles, including indolizines, imidazoles, indoles, and aniline, to enable the formation of various alkylated heteroarenes under very mild reaction conditions.