PPAR纬 Agonist from Chromolaena odorata
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- 作者：Man-Li Zhang ; Dianne Irwin ; Xiao-Ning Li ; Fran莽oise Sauriol ; Xiao-Wei Shi ; Yu-Fang Wang ; Chang-Hong Huo ; Li-Geng Li ; Yu-Cheng Gu ; Qing-Wen Shi
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：December 28, 2012
- 年：2012
- 卷：75
- 期：12
- 页码：2076-2081
- 全文大小：279K
- 年卷期：v.75,no.12(December 28, 2012)
- ISSN：1520-6025
文摘
A phytochemical investigation of Chromolaena odorata resulted in the isolation of five new compounds, 5a伪,6,9,9a尾,10-pentahydro-10尾-hydroxy-7-methylanthra[1,2-d][1,3]dioxol-5-one (1), 1,2-methylenedioxy-6-methylanthraquinone (2), 3-hydroxy-1,2,4-trimethoxy-6-methylanthraquinone (3), 3-hydroxy-1,2-dimethoxy-6-methylanthraquinone (4), and 7-methoxy-7-epi-medioresinol (5), together with 12 known compounds, odoratin (6), 3尾-acetyloleanolic acid (7), ursolic acid (8), ombuin (9), 4,2鈥?dihydroxy-4鈥?5鈥?6鈥?trimethoxychalcone (10), (鈭?-pinoresinol (11), austrocortinin (12), tianshic acid (13), cleomiscosin D (14), (鈭?-medioresinol (15), (鈭?-syringaresinol (16), and cleomiscosin A (17). All the compounds were evaluated for their PPAR纬 transactivation activity, and compound 6 showed moderate activity with an EC50 value of 3.10 渭M.