Self-Healing and Thermoresponsive Dual-Cross-Linked Alginate Hydrogels Based on Supramolecular Inclusion Complexes

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• 作者：Tianxin Miao ; Spencer L. Fenn ; Patrick N. Charron ; Rachael A. Oldinski
• 刊名：Biomacromolecules
• 出版年：2015
• 出版时间：December 14, 2015
• 年：2015
• 卷：16
• 期：12
• 页码：3740-3750
• 全文大小：810K
• ISSN：1526-4602

文摘

尾-Cyclodextrin (尾-CD), with a lipophilic inner cavity and hydrophilic outer surface, interacts with a large variety of nonpolar guest molecules to form noncovalent inclusion complexes. Conjugation of 尾-CD onto biomacromolecules can form physically cross-linked hydrogel networks upon mixing with a guest molecule. Herein, the development and characterization of self-healing, thermoresponsive hydrogels, based on host鈥揼uest inclusion complexes between alginate-graft-尾-CD and Pluronic F108 (poly(ethylene glycol)-b-poly(propylene glycol)-b-poly(ethylene glycol)), are described. The mechanics, flow characteristics, and thermal response were contingent on the polymer concentration and the host鈥揼uest molar ratio. Transient and reversible physical cross-linking between host and guest polymers governed self-assembly, allowing flow to occur under shear stress and facilitating complete recovery of the material鈥檚 properties within a few seconds of unloading. The mechanical properties of the dual-cross-linked, multi-stimuli-responsive hydrogels were tuned as high as 30 kPa at body temperature and are advantageous for biomedical applications such as drug delivery and cell transplantation.