Phaeolschidins A鈥揈, Five Hispidin Derivatives with Antioxidant Activity from the Fruiting Body of Phaeolus schweinitzii Collected in the Tibetan Plateau
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- 作者：Jun-Jie Han ; Li Bao ; Lu-Wei He ; Xiao-Qing Zhang ; Xiao-Li Yang ; Shao-Jie Li ; Yi-Jian Yao ; Hong-wei Liu
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：August 23, 2013
- 年：2013
- 卷：76
- 期：8
- 页码：1448-1453
- 全文大小：322K
- 年卷期：v.76,no.8(August 23, 2013)
- ISSN：1520-6025
文摘
Five new hispidin derivatives, phaeolschidins A鈥揈 (1鈥?b>5), as well as two known natural products, pinillidine (6) and hispidin (7), were isolated from the fruiting bodies of Phaeolus schweinitzii collected in the Tibetan Plateau. The structures of the new compounds were elucidated by spectroscopic methods. Phaeolschidins A鈥揇 (1鈥?b>4) are new bishispidins. Phaeolschidin E (5) is a new class of hispidin derivative in which one pyrrolidin-2-one moiety was linked to C-3 of hispidin. The antioxidant activity of 1鈥?b>7 was evaluated using three methods: the DPPH scavenging assay, the total antioxidant capacity assay, and the lipid peroxidation assay. Hispidin showed the strongest antioxidant activity of all tested compounds. This is the first report of secondary metabolites from the fungus P. schweinitzii.