A New Class of Silica Cross-Linked Micellar Core-Shell Nanoparticles

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• 作者：Qisheng Huo ; Jun Liu ; Li-Qiong Wang ; Yingbing Jiang ; Timothy N. Lambert ; and Erica Fang
• 刊名：Journal of the American Chemical Society
• 出版年：2006
• 出版时间：May 17, 2006
• 年：2006
• 卷：128
• 期：19
• 页码：6447 - 6453
• 全文大小：346K
• 年卷期：v.128,no.19(May 17, 2006)
• ISSN：1520-5126

文摘

Micellar nanoparticles made of surfactants and polymers have attracted wide attention in thematerials and biomedical community for controlled drug delivery, molecular imaging, and sensing; however,their long-term stability remains a topic of intense study. Here we report a new class of robust, ultrafinesilica core-shell nanoparticles formed from silica cross-linked, individual block copolymer micelles.Compared with pure polymeric micelles, the main advantage of the new core-shell nanoparticles is thatthey have significantly improved stability and do not break down during dilution. We also studied the drugloading and release properties of the silica cross-linked micellar particles, and we found that the new core-shell nanoparticles have a slower release rate which allows the entrapped molecules to be slowly releasedover a much longer period of time under the same experimental conditions. A range of functional groupscan be easily incorporated through co-condensation with the silica matrix. The potential to deliver hydrophobicagents into cancer cells has been demonstrated. Because of their unique structures and properties, thesenovel core-shell nanoparticles could potentially provide a new nanomedicine platform for imaging, detection,and treatment, as well as novel colloidal particles and building blocks for mutlifunctional materials.