Soluble, Clickable Polypeptides from Azide-Containing N-Carboxyanhydride Monomers
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- 作者：Allison J. Rhodes ; Timothy J. Deming
- 刊名：ACS Macro Letters
- 出版年：2013
- 出版时间：May 21, 2013
- 年：2013
- 卷：2
- 期：5
- 页码：351-354
- 全文大小：223K
- 年卷期：v.2,no.5(May 21, 2013)
- ISSN：2161-1653
文摘
We report a method for the synthesis of soluble, well-defined, azide-functionalized polypeptides via living polymerization of new azide-containing amino acid N-carboxyanhydride (NCA) monomers. Homo and diblock azidopolypeptides were prepared with controlled segment lengths using (PMe3)4Co initiator and were subsequently modified by reaction with functional alkyne reagents. The azide groups were found to be quantitatively converted to the corresponding triazole derivatives, and the functionalized polymers were obtained in high yield. This methodology provides a facile and straightforward method for preparation of functional and side-chain reactive, high molecular weight polypeptides.