Functional and Multifunctional Nanoparticles for Bioimaging and Biosensing

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• 作者：Subramanian Tamil Selvan ; Timothy Thatt Yang Tan ; Dong Kee Yi ; Nikhil R. Jana
• 刊名：Langmuir
• 出版年：2010
• 出版时间：July 20, 2010
• 年：2010
• 卷：26
• 期：14
• 页码：11631-11641
• 全文大小：1385K
• 年卷期：v.26,no.14(July 20, 2010)
• ISSN：1520-5827

文摘

Herein, we describe the synthesis of functional and multifunctional nanoparticles (NPs), derived from our recent work, for bioimaging and biosensing applications. The functionalized NPs involve quantum dots (QDs), magnetic particles (MPs) and noble metal NPs for the aforementioned applications. A diverse silica coating approaches (reverse microemulsion and thin silanization) are delineated for the design of water-soluble NPs. We also review the synthesis of silica-coated bifunctional NPs consisting of MPs and QDs for live cell imaging of human liver cancer cells (HepG2) and mouse fibroblast cells (NIH-3T3). Using silica coated NPs, various NPs that are functionalized with antibody, oligonucleotide, biotin and dextran are efficiently used for protein detection.