Resolution of tert-Butyl-1-(2-Methylnaphthyl)phosphine Oxide Using Selectors Identified from a Chemical Combinatorial Library

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• 作者：Jordan Blodgett ; Yan Wang ; Tingyu Li ; Prasad L. Polavarapu ; Jozef Drabowicz ; K. Michal Pietrusiewicz ; and Krystyna Zygo
• 刊名：Analytical Chemistry
• 出版年：2002
• 出版时间：October 15, 2002
• 年：2002
• 卷：74
• 期：20
• 页码：5212 - 5216
• 全文大小：70K
• 年卷期：v.74,no.20(October 15, 2002)
• ISSN：1520-6882

文摘

Resolution of racemic tert-butyl-1-(2-methylnaphthyl)phosphine oxide 1, a chiral phosphorus compound, wasachieved using selectors developed from a small peptidelibrary. Separation factors as high as 3.2 were observed.The library consists of 81 peptide-based potential chiralselectors on polymeric synthesis resins. The linker neededto immobilize the identified chiral selectors onto silica gelproved important in the chiral separation; a longer linkerprovided a significantly higher separation factor in thisstudy.