Effects of Carbon and Nitrogen Plasma Immersion Ion Implantation on In vitro and In vivo Biocompatibility of Titanium Alloy
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- 作者：Ying Zhao ; Sze Man Wong ; Hoi Man Wong ; Shuilin Wu ; Tao Hu ; Kelvin W. K. Yeung ; Paul K. Chu
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2013
- 出版时间：February 27, 2013
- 年：2013
- 卷：5
- 期：4
- 页码：1510-1516
- 全文大小：534K
- 年卷期：v.5,no.4(February 27, 2013)
- ISSN：1944-8252
文摘
Growth of bony tissues on titanium biomedical implants can be time-consuming, thereby prolonging recovery and hospitalization after surgery and a method to improve and expedite tissue-implant integration and healing is thus of scientific and clinical interests. In this work, nitrogen and carbon plasma immersion ion implantation (N鈥揚III and C鈥揚III) is conducted to modify Ti-6Al-4V to produce a graded surface layer composed of TiN and TiC, respectively. Both PIII processes do not significantly alter the surface hydrophilicity but increase the surface roughness and corrosion resistance. In vitro studies disclose improved cell adhesion and proliferation of MC3T3-E1 preosteoblasts and L929 fibroblasts after PIII. Micro-CT evaluation conducted 1 to 12 weeks after surgery reveals larger average bone volumes and less bone resorption on the N鈥揚III and C鈥揚III titanium alloy pins than the unimplanted one at every time point. The enhancements observed from both the in vitro and in vivo studies can be attributed to the good cytocompatibility, roughness, and corrosion resistance of the TiN and TiC structures which stimulate the response of preosteoblasts and fibroblasts and induce early bone formation. Comparing the two PIII processes, N鈥揚III is more effective and our results suggest a simple and practical means to improve the surface biocompatibility of medical-grade titanium alloy implants.